member-academic-staff

Yael Yaniv

Yael Yaniv
Assistant Professor
972(4)8294124
Silver 321
  • CV

    Education:

    2004-2007  Ph.D. in Biomedical Engineering, Technion-Israel Institute of Technology, Israel. Dissertation title: “Identification of the mechano-electrical feedback in the heart” Advisor: Assoc. Prof. Amir Landesberg 2002-2003  M.Sc. in Electrical Engineering, Technion-Israel Institute of Technology, Israel. Thesis title: “Identification of the sarcomere contraction control mechanisms” Advisors: Prof. Raphael Sivan and Assoc. Prof. Amir Landesberg. 1997-2002  B.Sc. in Electrical Engineering, Technion-Israel Institute of Technology, Israel. 1997-2002  B.Sc. in Mechanical Engineering, Technion-Israel Institute of Technology, Israel.

    Academic appointments:
    3/2014-  Assistant Professor in Biomedical Engineering, Technion-Israel Institute of Technology, Israel. 10/2012-2/2014 Research fellow in National Institute on Aging, National Institute of Health. 10/2007-9/2012 Visiting fellow in National Institute on Aging, National Institute of Health Advisors: Edward G. Lakatta, M.D. 7/2006-11/2006 Research scholar in Biomedical Engineering, Case Western Reserve University Advisors: Prof. William Stanley and Prof. Gerald Saidel.

    Honors and Awards:
    • Woman Excellence in Scientific Research Award, 2013. • Nathan W. Shock Post-Doctoral Poster Presentation award, 2012. • NIH Postdoctoral Mentor Award, 2012. • International Society of Heart Research, American Section, poster award, 2011. • Gordon Research Conference: Cardiac Arrhythmia Mechanisms poster award, 2011. • Gordon Research Conference: Cardiac Regulatory Mechanisms poster award, 2010. • Excellent Women Researcher in Engineering and Science award, Technion- Israel Institute of Technology, 2007. • Excellence in Teaching Award, Technion- Israel Institute of Technology, 2007. • Katzir travel fellowship, Weismann Institute, Israel, 2006. • Particular Gutwierth award, Technion- Israel Institute of Technology, 2006. • Biophysical Society Student Travel award, 2005. • Vivian Konigsberg Award for Excellence in Teaching, Technion- Israel Institute of Technology, 2005. • Particular Gutwierth award, Technion- Israel Institute of Technology, 2005. • International Congress of Physiological Sciences Travel award, 2005. • Sandor Szego award for excellence in teaching, Technion- Israel Institute of Technology, 2004. • Diploma with honors (summa cum laude), Electrical Engineering, Technion- Israel Institute of Technology, 2004. • First Award for best student presentation at the meeting of the "Israeli Society for Medical and Biological Engineering", Israel, 2004. • First Award, for best graduate student presentation, at the International Society of Physiology and Pharmacology meeting, Israel, 2003. • Diploma with honors (cum laude), Electrical Engineering, Technion- Israel Institute of Technology, 2002. • Diploma with honors (cum laude), Mechanical Engineering, Technion- Israel Institute of Technology, 2002.

  • Selected Publications

    Publications:

    See full list here Yaniv Y, Ahmet I, Liu J, Lyashkov AE, Guiriba TR, Okamoto Y, Ziman BD and Lakatta EG. Synchronization of sinoatrial node pacemaker cell clocks and its autonomic modulation impart complexity to heart beating intervals.   Heart Rhythm Accepted, 2014. Yaniv Y and Maltsev VA. “Numerical Modeling Calcium and CaMKII Effects in the SA Node.” Frontiers in Pharmacology Accepted, 2014. Yaniv Y, Lyashkov AE and Lakatta EG. “Impaired Signaling Intrinsic to Sinoatrial Node Pacemaker Cells Affects Heart Rate Variability during Cardiac Disease.” J Clin Trials 4 (152), 2167-0870.1000152, 2013. Yaniv Y, Stern M, Lakatta EG and Maltsev VA. “Mechanisms of beat-to-beat regulation of cardiac pacemaker cell function by Ca2+ cycling dynamics.” Biophysics Journal, 105(7):1551-1561, 2013. Maltsev A, Yaniv Y, Stern M, Lakatta EG and Maltsev VA. “RyR-NCX-SERCA local crosstalk ensures pacemaker cell function at rest and during the fight-or-flight reflex.” Circulation Research, 113(10):e94-e100. Yaniv Y, Lyashkov AE and Lakatta EG. “The Fractal-Like Complexity of Heart Rate Variability beyond Neurotransmitters and Autonomic Receptors: Signaling Intrinsic to Sinoatrial Node Pacemaker Cells”. Cardiovascular Pharmacology: Open access, Accepted, 2013. Yaniv Y, Syevda Sirenko, Ziman BD, Spurgeon HA, Maltsev VA and Lakatta EG.“ New evidence for coupled clock regulation of the normal automaticity of sinoatrial nodal pacemaker cells: Bradycardic effects of ivabradine are linked to suppression of intracellular Ca2+ cycling”. JMCC, 62C:80-89, 2013. Yaniv Y, Spurgeon HA, Ziman BD, Lyashkov AE, and Lakatta EG. “Mechanisms that match ATP supply to demand in cardiac pacemaker cells during high ATP demand”. Am. J. Physiol. 304(11): H1428-1438. 2013. Yaniv Y, Spurgeon HA, Ziman BD and Lakatta EG. “Ca2+/calmodulin-dependent protein kinase II (CaMKII) and sinoatrial nodal pacemaker cell energetics”. PLoS One, 8(2): e57079, 2013. Yaniv Y, Spurgeon HA, Lyashkov AE, Yang D, Ziman BD, Maltsev V, and Lakatta EG. Crosstalk between mitochondrial and sarcoplasmic reticulum Ca2+ cycling modulates cardiac pacemaker cell automaticity. PLoS One, 7(5):e37582, 2012. Yaniv Y, Maltsev VA, Escobar AL, Spurgeon HA, Ziman BD, Stern MD and Lakatta EG. Beat-to-beat Ca2+-dependent regulation of sinoatrial nodal pacemaker cell rate and rhythm. JMCC, 51(6):902-905, 2011. Yaniv Y, Juhaszova M, Lyashkov AE, Spurgeon HA, Sollott SJ and Lakatta EG. Ca2+-regulated-cAMP/PKA signaling in cardiac pacemaker cells links ATP supply to demand. JMCC, 51(5):740-748, 2011. Yaniv Y, Juhaszova M, Wang S, Fishbein KW, Zorov BD, and Sollott SJ. “Analysis of mitochondrial 3D-deformation in cardiomyocytes during active contraction reveals passive structural anisotropy of orthogonal short axes”, PLoS One, 6(7):e21985, 2011.

  • Main Research Interests

    Research interests:

    Bioenergetics, Calcium signaling, Cardiac electrophysiology, Cell Biophysics, Heart rate variability analysis, Mathematical modeling of the biochemical and bioenergetics signaling in the heart, Mechanical interaction of the mitochondria and the cytoskeleton, Sinoatrial node cells activity.